ea0081oc10.6 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022
Masa Sabela Casado
, De Oliveira Diz Tadeu
, Miguens Marta Varela
, Gonzalez Carlos Dieguez
, Carro Sulay Tovar
Liver-expressed antimicrobial peptide 2 (LEAP-2) has been recently characterized as an endogenous GHSR1a antagonist. LEAP-2 is produced mainly in the liver, and it was described that an acute ghrelin administration blocks food intake, GH release and normalize glucose levels during chronic caloric restriction. For this reason, it could be considered as a key endocrine factor in the regulation of systemic energy metabolism. Nevertheless, the exact mechanism of action is still un...